Takayama Misa

Takayama Misa is a level 90 Bard-Sword Saint and is one of the three Drei Klauen in D.D.D, the biggest battle guild in Akihabara. She has two Overskills, Hermes Link and Guardian Wolf.

In real life, she is a kindergarten teacher; her real name is the same as her in-game name, with the same pronunciation (although technically, it's Misa Takayama, since Japanese naming places the family name first).

Appearance
Misa wears the typical D.D.D-style uniform, with her Drei Klauen color being blue (as opposed to Rieze's red and Kushi Yatama's green). In battle, she wears a breastplate and pauldrons instead of her usual jacket, a detail that is omitted in the anime.

Personality
From her interactions with Krusty and other members in her guild, she seems to be the "mother" of the guild, scolding members and even the guild master whenever they goof off or get lazy.

Prior to the Catastrophe
Misa was a kindergarten teacher, and ran her classroom like a military sergeant. It apparently made her quite popular with the kids.

The Catastrophe arc
Misa reports to Krusty about happenings in Akiba, mentioning Maryelle's meeting with Ichimonjinosuke Akaneya, Woodstock W, and other smaller guilds' guild masters. She then piques his interest by reporting that Shiroe, Naotsugu, and Akatsuki had gone to Susukino.

Round Table Alliance arc
Misa is shown alongside Krusty when Maryelle and Shiroe discuss the current situation in Akiba.

After Krusty receives the invitation to attend the Round Table Conference, she confirms with him that their next raid was canceled due to overlapping schedules. He then tells her that he was less interested in the conference itself than in Shiroe, who was one of the organizers.

Misa and Rieze accompany Krusty to the Round Table Conference and watch as the events unfold. After the conclusion of the conference, Misa observes one of the Eastal scouts that was watching their guild hall and asks Krusty if a war with the People of the Land was possible.

Misa attends the ball held by the Eastal nobles and dresses up for the event like the other representatives of the Round Table Council, as she accompanies Krusty.

Return of the Goblin King arc
After Krusty, Rayneshia, Shiroe, and Akatsuki returned to Akiba by Griffin, Misa implicitly rode her own back to Akiba to prepare for the journey on the Ocypete, as she is seen on the ship as it prepares to head out.

Fallen Guardian arc arc
Along with members of D.D.D. and the Black Sword Knights, Misa goes to finish the Return of the Goblin King quest by eliminating the Goblin King. However, during that time, the flavor text on her scythe ends up becoming real, and during the events that unfold because of it, she ends up losing her right arm as Krusty vanishes after trying to save her.

Upon returning to Akiba, her right hand never grew back, causing her to get an artificial one. Afterwards, she disappears from the guild for a while, leaving Rieze with the task of looking after the guild.

Log Horizon: West Wind Brigade
Misa is alongside Krusty with her weapon in tow when they go to fetch the two new players that the West Wind Brigade were protecting. Upon meeting them, Krusty instantly moves to attack Soujiro, but is blocked. Misa then tells Krusty to stop fooling around. Before they leave, she is seen next to Nazuna, possibly exchanging information.

Trivia

 * Her name is a pun, being able to be read as both "Misa" and "Sansa." The former is the real pronunciation, while the latter is her nickname, as it also can mean the military rank "Major."
 * She shares a voice actress with Nazuna.